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KMID : 1036720140470050321
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Journal of Nutrition and Health
2014 Volume.47 No. 5 p.321 ~ p.329
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Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey
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Jung In-Kyung
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Abstract
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Purpose: The aim of this study was to determine the relationship between serum concentrations of 25-hydroxyvitamin D
[25(OH)D] and chronic obstructive pulmonary disease (COPD) prevalence.
Methods: The analysis was performed using data from the Fifth Korean National Health and Nutrition Examination Survey, a cross-sectional survey of the Korean civilian population conducted from 2010 to 2012. The analyses were restricted to males who were 40 years of age and above. Complex sample multiple logistic regression analyses were used to examine the associations of COPD prevalence with 25(OH)D and other factors.
Results: FEV1/FEV6 varied significantly with smoking status, age, household income, education level, occupation, body mass index (BMI), and physical activity (p < 0.05). In univariate analysis, smoking status, BMI, household income, education level, and occupation showed association with COPD (p < 0.05), but vitamin D was not associated with COPD (p = 0.078). However, when adjusted with smoking status, household income, education level, occupation, BMI, age, and smoking index, the lowest quartile of 25(OH)D showed OR 1.643 (95% CI 1.161-2.236) compared to 3rd quartile (p = 0.024).
Conclusion: A significant relationship was observed between serum concentration of 25(OH)D
and COPD.
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KEYWORD
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vitamin D, 25(OH)D, COPD, FEV1/FEV6, logistic regression analysis
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